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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
New Alzheimer's disease locus on chromosome 8
V Giedraitis1, M Hedlund, L Skoglund
1Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden . Vilmantas.Giedraitis@pubcare.uu.se
Journal of Medical Genetics
|July 11, 2006
Summary
Family history is a key dementia risk factor. This study identified a potential Alzheimer's disease susceptibility locus on chromosome 8, suggesting a dominant inheritance pattern in affected families.
Area of Science:
- Genetics
- Neurology
- Human Disease Genetics
Background:
- Family history is a significant risk factor for dementia.
- Analyzing families with clear inheritance patterns aids in discovering new disease genes.
Purpose of the Study:
- To map susceptibility regions for Alzheimer's disease (AD).
Main Methods:
- Genome scan of 369 microsatellite markers in 12 Swedish families.
- Investigated age at onset and excluded mutations in known early-onset AD genes.
- Genotyped for APOE, with no clear linkage to the epsilon4 allele observed.
Main Results:
- Identified a shared extended haplotype on chromosome 8q in two families with Alzheimer's disease.
- Achieved a non-parametric multipmarker LOD score of 4.2 in one family, indicating linkage.
- Observed shared haplotypes among affected members in both families within the 8q region.
Conclusions:
- Propose the existence of a dominantly acting Alzheimer's disease susceptibility locus on chromosome 8 based on family data.
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