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Updated: Aug 7, 2026

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
[Short bowel syndrome in children - own experience]
Wanda Bako1, Andrzej Marek, Grazyna Sikorska-Wiśniewska
1Klinika Pediatrii, Gastroenterologii i Onkologii Dzieciecej, Akademia Medyczna, ul. Nowe Ogrody 1-6, 80-803 Gdansk, Poland.
Insights
Children with short bowel syndrome (SBS) require long-term care and parenteral nutrition for survival and normal development. Despite initial growth delays, final outcomes can be positive with comprehensive medical support.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Nutritional Support
Background:
- Short bowel syndrome (SBS) in children often necessitates extensive intestinal resection.
- Congenital anomalies are primary causes of SBS in infants and young children.
- Total parenteral nutrition (TPN) is a critical intervention for SBS management.
Observation:
- This study retrospectively analyzed 5 children with SBS post-intestinal resection.
- Clinical status, somatic development, and laboratory tests were evaluated.
- Common complications included diarrhea, anemia, cholestasis, and catheter-related issues.
Findings:
- TPN was essential for survival and normal somatic development in children with SBS.
- Vitamin B12 deficiency and lactic acidosis (secondary to biotin deficiency) were noted in some cases.
- Despite initial growth retardation, final anthropometric evaluations were normal in all patients.
Implications:
- Long-term, multidisciplinary care is vital for children with SBS.
- Biotin deficiency should be considered in SBS patients with complicated acid-base balance.
- Parenteral nutrition plays a crucial role in achieving positive long-term outcomes for pediatric SBS patients.
The Aim:
of this study was to analyze the clinical status of children with short bowel syndrome (SBS) shortly after the resection and during following years.
Material And Methods:
we reviewed retrospectively 5 children with SBS aged from 2 years and 7 months till 14 years and 5 months, who were on total parenteral nutrition due to intestinal resection. The resection was performed, when they were either newborns or infants. In the analysis we considered somatic development and laboratory tests results. In 4 cases the cause for extensive bowel resection were congenital anomalies of the intestine, in one case it was intestinal necrosis as result of invagination.
Results:
in all children there was diarrhea, during postoperative period and when oral caloric intake was increased and when loss of weight was observed. Most common complications included hypochromic anaemia and cholestasis. Moreover, in 2 children with resection of distal region of the ileum and ascending colon, we observed vitamin B12 deficiency and recurrent lactic acidosis due to secondary biotin deficiency. Catheter complications were one of the main problems. 3 patients developed sepsis. Occlusion or mechanic damage of the catheter were also observed. Despite initial severe retardation in somatic development, final anthropometric evaluation in all children was found to be normal.
Conclusions:
1. Congenital intestinal and mesenteric defects were the most common reasons for SBS in the youngest children. 2. Parenteral nutrition is the cardinal element in the management. It was crucial for survival and further normal somatic development, even in children after extensive intestinal resection. 3. Lactic acidosis due to biotin deficiency must be considered if acid-base balance restoration is complicated in children with SBS. 4 Children with SBS after resection need long-term and multi specialistic medical care.
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