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HPLC method for determination of the purity of a mebrofenin-ligand for 99mTc-complexes
E Mikiciuk-Olasik1, I Bilichowski, E Wojewoda
1Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódź, Poland. eolasik@pharm.am.lodz.pl
Abstract:
A reversed-phase HPLC method has been developed for the estimation of purity and quantitative determination of mebrofenin UV detection at 205 nm was used. The stability of mebrofenin alone and in the presence of stannous chloride at 25 degrees C was studied. No decomposition product was found and there was no influence of SnCl2 on the stability of mebrofenin.
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