Related Experiment Video
Updated: Aug 7, 2026
Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
International Central Nervous System and Ocular Lymphoma Workshop: recommendations for the future
Robert B Nussenblatt1, Chi-Chao Chan, Wyndham H Wilson
1Laboratory of Immunology, National Eye Institute, NIH, 10 Center Drive, Building 10, Room 10S219, Bethesda, MD, 20892, USA. DrBob@nei.nih.gov
Purpose:
To bring together multidisciplinary experts to discuss primary central nervous system lymphoma (PCNSL) and primary intraocular lymphoma (PIOL).
Methods:
NIH campus workshop discussion focusing on future work in both clinical and basic lymphoma research.
Results:
The discussion lead to recommendations on elucidating disease pathobiology, improving diagnostic accuracy and sensitivity, and novel therapeutic strategies.
Conclusions:
Approaches which have been successfully applied to other neoplasms, such as microarray, may be applied to improve diagnostic accuracy and sensitivity of PCNSL and PIOL and should be systematically incorporated into clinical trials of both. Development of animal models of PCNSL and PIOL may be useful in understanding the unique ocular and CNS milieu. Disease detection by radiological, nuclear medicine, molecular and flow cytometric approaches should be systematically studied to improve early diagnosis, accurate staging, and response evaluation. Improved therapy remains the ultimate goal. Efforts in these arenas should be coordinated on a national and international level.
