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Updated: Aug 7, 2026
14:33
The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
Published on: May 6, 2010
[Olfactory bulb neurogenesis and its neurological impact]
Antoine de Chevigny1, Pierre-Marie Lledo
1Institut Pasteur, Laboratoire Perception et mémoire, CNRS URA 2182, 25, rue du Docteur-Roux, 75724 Paris Cedex 15, France.
Medecine Sciences : M/S
|July 11, 2006
Summary
The adult mammalian brain can generate new neurons, particularly in the hippocampus and olfactory bulb. This neurogenesis offers hope for brain repair therapies after injury.
Area of Science:
- Neuroscience
- Cell Biology
- Regenerative Medicine
Context:
- The adult mammalian brain was long believed incapable of generating new neurons.
- Neuronal turnover is now recognized in specific brain regions like the hippocampus and olfactory bulb.
- Neural stem cells in the subgranular zone and subventricular zone are responsible for adult neurogenesis.
Purpose:
- To review the organization of the subventricular zone neurogenic niche.
- To examine intrinsic and extrinsic factors regulating adult neurogenesis.
- To discuss the potential for enhancing brain repair through endogenous progenitor cells.
Summary:
- Adult neurogenesis occurs in the hippocampus and olfactory bulb from neural stem cells.
- Factors influencing stem cell proliferation, migration, differentiation, and survival are increasingly understood.
- Neurogenesis is upregulated in response to brain injury, with subventricular zone progenitors contributing to repair.
Impact:
- The adult brain possesses an intrinsic capacity for cell replacement and regeneration.
- Strategies to enhance endogenous neurogenesis show promise for treating brain damage.
- This research holds potential for developing novel regenerative therapies for neurological disorders.
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