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Compressed mini-tablets as a biphasic delivery system.

Carla M Lopes1, José Manuel Sousa Lobo, João F Pinto

  • 1Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal. clopes@ff.up.pt

International Journal of Pharmaceutics
|July 11, 2006
PubMed
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This study introduces biphasic mini-tablet systems for controlled drug delivery. Formulations with hydroxypropyl methylcellulose (HPMC) mini-tablets achieved zero-order sustained drug release for up to 8 hours.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Developing controlled drug release systems is crucial for therapeutic efficacy and patient compliance.
  • Biphasic drug delivery offers a strategy to achieve both immediate and sustained release profiles from a single dosage form.

Purpose of the Study:

  • To design and evaluate compressed mini-tablet systems exhibiting biphasic drug release.
  • To investigate the impact of mini-tablet composition and number on drug release kinetics.
  • To achieve zero-order sustained drug release over an extended period.

Main Methods:

  • Formulation of compressed mini-tablet systems with a fast-releasing outer layer and sustained-release mini-tablets.
  • Inclusion of varying numbers (10 or 21) and compositions (hydroxypropyl methylcellulose - HPMC, or ethylcellulose - EC) of mini-tablets.

Related Experiment Videos

  • In vitro dissolution testing to assess drug release profiles and kinetics.

    • Main Results:

    • The developed systems demonstrated a biphasic drug release pattern.
    • The fast-releasing phase dissolved within the initial 2 minutes.
    • Mini-tablets containing HPMC exhibited drug release rates suitable for approaching zero-order kinetics over 8 hours, with variations observed based on formulation parameters.

    Conclusions:

    • Compressed mini-tablet systems can effectively achieve biphasic drug release.
    • HPMC-based mini-tablets are promising for developing zero-order sustained drug delivery systems.
    • The formulation parameters significantly influence the drug release rate and profile.