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Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma
Published on: August 31, 2022
Current staging of hepatocellular carcinoma: imaging implications
P Bhosale1, J Szklaruk, P M Silverman
1Department of Radiology, Division of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. Priya.Bhosale@di.mdacc.tmc.edu
Summary
Hepatocellular carcinoma (HCC) incidence is increasing in the USA, primarily affecting individuals aged 50-70. This paper details the multimodal approach to HCC diagnosis, surveillance, and treatment.
Area of Science:
- Hepatology
- Oncology
- Diagnostic Imaging
Background:
- Rising incidence of hepatocellular carcinoma (HCC) in the USA over the past two decades.
- HCC predominantly impacts individuals aged 50-70 years.
- Chronic hepatitis B virus infection is a primary etiological factor for HCC.
Purpose of the Study:
- To discuss the multimodal approach for the diagnosis and surveillance of hepatocellular carcinoma.
- To present the latest information on HCC staging, treatment, epidemiology, clinical presentation, pathology, and laboratory findings.
Main Methods:
- Utilizing CT, MRI, and ultrasound for diagnosis based on vascularity and enhancement features.
- Reviewing current literature and guidelines for staging and treatment strategies.
- Analyzing epidemiological data and clinical presentation characteristics.
Main Results:
- Hepatocellular carcinoma is an indolent tumor associated with low life expectancy.
- Imaging techniques like CT, MRI, and ultrasound are crucial for diagnosis.
- A comprehensive understanding of epidemiology, pathology, and laboratory findings is essential.
Conclusions:
- Early diagnosis and surveillance are critical for managing hepatocellular carcinoma.
- Multimodal diagnostic and therapeutic strategies improve patient outcomes.
- Continued research into HCC etiology, particularly hepatitis B virus, is vital.
