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Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker

Nola Hylton1

  • 1University of California, San Francisco, San Francisco, CA 94143-1290, USA. nola.hylton@radiology.ucsf.edu

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|July 11, 2006
PubMed

Insights

Dynamic contrast-enhanced MRI (DCE-MRI) noninvasively measures tumor microvasculature for oncology. DCE-MRI shows promise as an imaging biomarker for assessing antiangiogenic cancer treatment effects in clinical trials.

Area of Science:

  • Oncology
  • Medical Imaging
  • Radiology

Background:

  • Dynamic contrast-enhanced MRI (DCE-MRI) is a noninvasive technique.
  • It measures tumor microvasculature properties in oncology.
  • DCE-MRI has potential as an imaging biomarker for antiangiogenic cancer therapies.

Purpose of the Study:

  • To review the methodology of DCE-MRI.
  • To discuss current data on DCE-MRI for treatment response assessment.
  • To identify challenges in applying DCE-MRI in clinical trials.

Main Methods:

  • Review of existing literature on DCE-MRI methodology.
  • Analysis of data regarding DCE-MRI application in clinical trials.
  • Discussion of challenges and future directions.

Main Results:

  • DCE-MRI provides insights into tumor microvasculature.
  • The technique is being explored for assessing antiangiogenic treatment efficacy.
  • Challenges exist in standardizing DCE-MRI for clinical trial use.

Conclusions:

  • DCE-MRI is a valuable tool for noninvasive assessment of tumor microvasculature.
  • Its application as an imaging biomarker for antiangiogenic therapies is promising.
  • Further research is needed to overcome challenges for widespread clinical trial implementation.

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