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Influence of aging on the rat urinary bladder function.

M Saito1, M Gotoh, K Kato

  • 1Department of Urology, Nagoya University School of Medicine, Japan.

Urologia Internationalis
|January 1, 1991
PubMed
Summary
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Aging alters rat bladder function, increasing responses to norepinephrine, adenosine triphosphate, and serotonin, potentially causing bladder instability. However, aged bladders showed weaker responses to calcium, contributing to impaired detrusor contractility in elderly individuals.

Area of Science:

  • Urology
  • Gerontology
  • Physiology

Background:

  • Bladder function changes significantly with aging.
  • Understanding age-related alterations in bladder physiology is crucial for addressing urinary dysfunction in elderly populations.

Purpose of the Study:

  • To investigate the in vitro changes in rat bladder function associated with aging.
  • To examine the effects of neurotransmitters and inorganic ions on bladder muscle strips from young and aged rats.

Main Methods:

  • Muscle strips from young (6-month-old) and aged (16- and 24-month-old) rats were used for in vitro studies.
  • Responses to eight neurotransmitters and four inorganic ions were analyzed.

Main Results:

  • Aged rat bladders exhibited significantly greater contractile responses to norepinephrine, adenosine triphosphate, and serotonin compared to young bladders.

Related Experiment Videos

  • Aged rat bladders showed significantly weaker magnitude and speed of response to calcium, potentially explaining impaired detrusor contractility.
  • No significant age-related differences were observed in responses to acetylcholine, prostaglandin F2 alpha, angiotensin II, vasoactive intestinal polypeptide, KCl, BaCl2, and MgCl2.

    • Conclusions:

    • Increased contractile responses to certain agents in aged bladders may contribute to bladder instability in the elderly.
    • Reduced responsiveness to calcium in aged bladders likely underlies impaired detrusor contractility observed in older individuals.
    • Specific neurotransmitters and ions do not appear to be affected by aging in rat bladder function.