Synthesis and HPLC evaluation of carboxylic acid phases on a hydride surface
Joseph J Pesek1, Maria T Matyska, Surekha Gangakhedkar
1Department of Chemistry, California State University, One Washington Square, San Jose, CA 95192, USA. pesek@sjsu.edu
Abstract:
Three organic moieties containing carboxylic acid functional groups are attached to a particulate silica surface through silanization/hydrosilation. Two compounds (undecylenic acid and 10-undecynoic acid) have 11 carbon chains and the other is a five-carbon acid (pentenoic acid). Bonding is confirmed through carbon elemental analysis, diffuse reflectance infrared fourier transform spectroscopy, and carbon-13 and silicon-29 CP-MAS NMR spectroscopy. The bonded phases are tested by HPLC using PTH amino acids, nucleic acids, theophylline-related compounds, anilines, benzoic acid compounds, choline, and tobramycin. The latter two compounds are used to investigate the aqueous normal phase properties of the three bonded materials.
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