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Published on: June 30, 2013
Pathogenesis of osteopenia/osteoporosis induced by highly active anti-retroviral therapy for AIDS
George Pan1, Zhen Yang, Scott W Ballinger
1Department of Pathology, The University of Alabama at Birmingham, 701 19 Street S., LHR 504 Birmingham, AL 35294, USA.
Abstract:
The advent of highly active anti-retroviral therapy (HAART) has dramatically decreased the rate of AIDS-related mortality and significantly extended the life span of patients with AIDS. A variety of metabolic side effects are associated with these therapies, one of which is metabolic bone disease. A higher prevalence of osteopenia and osteoporosis in HIV-infected patients receiving anti-retroviral therapy than in patients not on therapy has now been reported in several studies. Several factors have been demonstrated to influence HIV-associated decreases in bone mineral density (BMD), including administration of nucleoside reverse transcriptase inhibitors (NRTIs). In this article, discussion will focus on the molecular pathogenesis and treatment of HAART-associated osteopenia and osteoporosis.
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