Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone destruction in multiple myeloma.

Toshio Matsumoto1, Masahiro Abe

  • 1Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. toshimat@clin.med.tokushima-u.ac.jp

Annals of the New York Academy of Sciences
|July 13, 2006
PubMed
Summary

Multiple myeloma cells cause bone destruction by increasing bone breakdown and inhibiting bone formation. Understanding these mechanisms may lead to new therapies for bone lesions in multiple myeloma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HAC1 contributes to stress adaptation and virulence in the emerging fungal pathogen Candida auris.

Medical mycology·2026
Same author

Influence of hypoxic conditions on Trichosporon asahii virulence in a Galleria mellonella infection model.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same author

Clinical and Microbiological Insights Into Invasive Fusariosis Following Allogeneic Hematopoietic Stem Cell Transplantation: A 15-Year Single-Center Analysis.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Comparative Evaluation of 3D-QALAS Myelin Volume Fraction, Inhomogeneous Magnetization Transfer, and Myelin Water Fraction.

AJNR. American journal of neuroradiology·2026
Same author

Post-radiofrequency ablation empyema-a staged multidisciplinary protocol for colonic and diaphragmatic perforation: a case report.

AME case reports·2026
Same author

A modified Cerfolio technique for robotic pulmonary resection: a retrospective comparison with the conventional approach.

General thoracic and cardiovascular surgery·2026

Area of Science:

  • Oncology
  • Bone Biology
  • Cell Signaling

Background:

  • Multiple myeloma (MM) is a cancer of plasma cells leading to bone lesions.
  • MM cells disrupt bone remodeling by increasing osteoclast activity and decreasing osteoblast activity.

Purpose of the Study:

  • To elucidate the mechanisms by which MM cells induce bone destruction.
  • To identify molecular targets for therapeutic intervention in MM-related bone disease.

Main Methods:

  • Analysis of signaling pathways involved in osteoclastogenesis and osteoblastogenesis in the bone marrow microenvironment.
  • Investigating the role of secreted factors like MIP-1alpha, MIP-1beta, and sFRP-2 in MM bone disease.

Main Results:

  • MM cells promote bone resorption via increased RANK ligand and decreased osteoprotegerin.

Related Experiment Videos

  • Macrophage inflammatory proteins (MIP)-1alpha and MIP-1beta contribute to enhanced bone resorption.
  • MM cells suppress bone formation through factors like secreted Frizzled-related protein (sFRP)-2.
  • A vicious cycle exists between osteoclasts and MM cells, promoting tumor growth and bone destruction.
  • MM cells and osteoclasts cooperate to enhance angiogenesis, further exacerbating bone destruction and MM expansion.

    • Conclusions:

    • MM cells actively induce bone destruction by enhancing resorption and suppressing formation.
    • Targeting the molecular mechanisms of MM-induced bone disease offers potential therapeutic strategies.