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Updated: Jul 17, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
beta A4 amyloid protein deposition in brain after head trauma
G W Roberts1, S M Gentleman, A Lynch
1Department of Anatomy, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
Abstract:
Previous reports have suggested that both repetitive head trauma and a single injury can be associated with the presence of diffuse beta A4 amyloid protein plaques in long-term survivors. We have studied sixteen patients (aged 10-63 years) who sustained head injury and survived for only 6-18 days. Immunostaining with an antibody to beta A4 amyloid showed extensive deposits of the protein in the cortex in six of the sixteen patients (38%). Thus, severe head injury can trigger beta A4 deposition in the brain within days.
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