Adrenal insufficiency in T-cell lymphoma

Area of Science:

• Oncology
• Hematology
• Endocrinology

Background:

• Primary adrenal lymphoma (PAL) is an exceptionally rare T-cell neoplasm.
• Adrenal insufficiency can be a presenting symptom of PAL.

Observation:

• A 42-year-old woman presented with constitutional symptoms including fevers and night sweats.
• Diagnosis was confirmed as primary adrenal T-cell lymphoma (PATL) with associated adrenal insufficiency.

Findings:

• The patient expired two months post-chemotherapy and prednisolone treatment.
• Literature review suggests poor survival rates with single therapeutic modalities for PAL.
• One reported case of adrenectomy followed by radiotherapy achieved long-term survival.

Implications:

• Combined therapeutic modalities might offer a better prognosis for PATL patients.
• Further research with larger patient cohorts is necessary to establish optimal treatment strategies.
• Early diagnosis and multimodal treatment approaches are crucial for managing this rare condition.