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Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli

Luda Diatchenko1, Andrea G Nackley, Gary D Slade

  • 1Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA Australian Researcher Center for Population Oral Health, Dental School, University of Adelaide, Australia Department of Oral Medicine, Chulalongkorn University, Bangkok, Thailand NIDCR, NIH, DHHS, Bethesda, MD, USA NIAAA, NIH, DHHS, Rockville, MD, USA Department of Pharmacology, University of North Carolina at Chapel Hill, NC, USA.

Pain
|July 14, 2006
PubMed
Summary

Genetic variations in catechol-O-methyltransferase (COMT) influence pain sensitivity. Specific COMT haplotypes impact overall pain responses, while the val(158)met polymorphism is linked to temporal summation of heat pain.

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