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The utilisation of peripherally-administered intravenous nutrient solutions
D T Hansell1, J W Davies, A Shenkin
1University Departments of Surgery and Biochemistry, Royal Infirmary, Glasgow G31 2ER. U.K.
Clinical Nutrition (Edinburgh, Scotland)
|December 1, 1989
Summary
Peripheral intravenous nutrition regimens were compared in colorectal cancer surgery patients. A glucose, amino-acid, and fat (GAF) regimen improved nitrogen balance and is recommended for nutritional support.
Area of Science:
- Clinical Nutrition
- Surgical Oncology
- Metabolic Studies
Background:
- Post-operative nutritional support is crucial for recovery after colorectal cancer surgery.
- Evaluating different peripherally-administered intravenous nutritional regimens is essential for optimizing patient outcomes.
Purpose of the Study:
- To compare the metabolic effects of three intravenous nutritional regimens (dextrose-saline, amino-acid, and glucose-amino-acid-fat) in patients undergoing colorectal cancer surgery.
- To assess the impact of these regimens on substrate oxidation and nitrogen balance during the early post-operative period.
Main Methods:
- A randomized study involving 42 patients receiving one of three intravenous nutritional regimens for the first four post-operative days.
- Indirect calorimetry was used to measure pre- and post-operative fat and carbohydrate oxidation.
- Nitrogen balance was calculated to assess protein metabolism.
Main Results:
- The amino-acid (AA) regimen led to decreased carbohydrate oxidation and increased fat oxidation post-operatively.
- The dextrose-saline (DS) and glucose-amino-acid-fat (GAF) regimens did not significantly alter substrate oxidation.
- Cumulative nitrogen balance was significantly better in the GAF group compared to both DS and AA groups.
Conclusions:
- The glucose, amino-acid, and fat (GAF) regimen is recommended for peripheral intravenous nutritional support in patients recovering from colorectal cancer surgery.
- GAF regimen demonstrates superior nitrogen retention compared to standard dextrose-saline and amino-acid only regimens.
- Optimizing post-operative nutrition with GAF may enhance recovery and metabolic stability.
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