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Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Base-base interactions in the minor groove of double-stranded DNA
Tongfei Wu1, Koen Nauwelaerts, Arthur Van Aerschot
1Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Abstract:
A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A-T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair.
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