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No effects of probiotics on atopic dermatitis in infancy: a randomized placebo-controlled trial

M L Brouwer1, S A A Wolt-Plompen, A E J Dubois

  • 1Department of Paediatrics, Division of Paediatric Pulmonology, University Medical Center Groningen, Beatrix Children's Hospital, Groningen, The Netherlands. m.l.brouwer@bkk.umbg

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|July 15, 2006
PubMed

Insights

Probiotic supplementation did not significantly improve atopic dermatitis (AD) symptoms or immunological markers in infants. This study found no clinical benefit of using these specific probiotic strains for infantile AD.

Area of Science:

  • Immunology
  • Pediatrics
  • Microbiology

Background:

  • Probiotics are investigated for potential benefits in preventing and treating allergic diseases, especially in infants with atopic dermatitis (AD).
  • Previous studies suggest a possible therapeutic role for probiotics in managing sensitization and atopic conditions.

Purpose of the Study:

  • To assess the clinical and immunological impact of supplementing a hydrolyzed formula with two specific probiotic strains.
  • To evaluate the effects on the symptoms of atopic dermatitis in infants.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving infants under 5 months with AD.
  • Infants received a hydrolyzed whey formula with either Lactobacillus rhamnosus, Lactobacillus GG, or placebo for 3 months.
  • Clinical severity (SCORAD), allergic sensitization (IgE levels, skin prick tests), and inflammatory markers were assessed.

Main Results:

  • No statistically significant differences were observed in SCORAD, sensitization, or inflammatory parameters between the probiotic and placebo groups.
  • Cytokine production (IL-4, IL-5, IFN-gamma) also showed no significant changes.
  • Cow's milk allergy (CMA) was diagnosed in only four infants.

Conclusions:

  • The studied probiotic bacteria demonstrated no significant clinical or immunological effects in infants with atopic dermatitis.
  • Oral supplementation with these specific probiotic strains is unlikely to substantially impact infantile AD symptoms.
Abstract

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