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Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
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OPA1 and PARL keep a lid on apoptosis

Eyal Gottlieb1

  • 1Apoptosis and tumour physiology laboratory, Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow, Scotland G61 1BD, UK. e.gottlieb@beatson.gla.ac.uk

Cell
|July 15, 2006
PubMed
Summary

Mitochondrial cristae shape changes are vital for releasing cytochrome c during apoptosis. PARL and OPA1 proteins critically regulate this cristae remodeling process, impacting cell death.

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