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Updated: Aug 7, 2026
05:51
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Interleukin-1 and occlusive arterial diseases
Masatoshi Kusuhara1, Kikuo Isoda, Fumitaka Ohsuzu
1First Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-0042, Japan. mkusu@ndmc.ac.jp
Summary
Interleukin-1 (IL-1) and its inhibitor IL-1 receptor antagonist (IL-1Ra) are involved in vascular diseases. This review explores IL-1
Area of Science:
- Immunology
- Cardiovascular Biology
- Cytokine Signaling
Background:
- Interleukin-1 (IL-1) is a key pro-inflammatory cytokine regulating immune and inflammatory responses.
- IL-1 receptor antagonist (IL-1Ra) is the endogenous inhibitor of IL-1 activity.
- Both IL-1 and IL-1Ra are expressed in the vessel wall, suggesting roles in vascular pathology.
Purpose of the Study:
- To review recent advances in understanding IL-1's mechanism in occlusive arterial diseases.
- To specifically examine the role of IL-1 in neointimal hyperplasia and atherosclerosis using a mouse model.
Main Methods:
- Literature review of recent studies on IL-1 and IL-1Ra in vascular disease.
- Focus on research utilizing mouse models of occlusive arterial diseases.
Main Results:
- IL-1 plays a significant role in the development and progression of vascular diseases.
- Evidence suggests IL-1 contributes to neointimal hyperplasia and atherosclerosis.
- IL-1Ra's counter-regulatory function in these processes is highlighted.
Conclusions:
- IL-1 is a critical mediator in the pathogenesis of occlusive arterial diseases.
- Understanding IL-1 signaling in the vessel wall is crucial for developing therapeutic strategies.
- Mouse models provide valuable insights into IL-1's role in vascular inflammation and disease.
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