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Electrohydrodynamic atomization for biodegradable polymeric particle production.

Jingwei Xie1, Liang Kuang Lim, Yiyong Phua

  • 1Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117576 Singapore.

Journal of Colloid and Interface Science
|July 18, 2006
PubMed
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Electrohydrodynamic atomization (EHDA) effectively produces biodegradable polymeric nanoparticles for drug delivery. This method allows control over particle size and morphology by adjusting processing parameters.

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biotechnology

Background:

  • Electrohydrodynamic atomization (EHDA) is a versatile technique with applications in mass spectroscopy, thin film deposition, and pharmaceutical production.
  • Biodegradable polymeric micro- and nanoparticles are crucial for advanced drug delivery systems.

Purpose of the Study:

  • To investigate the use of EHDA for fabricating biodegradable polymeric micro- and nanoparticles.
  • To systematically analyze the impact of various processing parameters on particle characteristics.

Main Methods:

  • Utilized EHDA to produce polymeric particles, investigating parameters like polymer concentration, flow rate, surfactants, organic salt, and setup configurations.
  • Employed organic salts to enhance solution conductivity for nanoparticle formation.

Related Experiment Videos

  • Adjusted experimental setups to control solvent evaporation rates for solid and porous particle fabrication.

    • Main Results:

    • Achieved controllable particle size and morphology by manipulating EHDA processing parameters.
    • Successfully produced poly(lactic-co-glycolic acid) (PLGA) nanoparticles around 250 nm.
    • Demonstrated stable cone spray formation and reproducibility at higher flow rates.
    • Fabricated both solid and porous polymeric particles.

    Conclusions:

    • EHDA is a highly promising technique for the controlled fabrication of polymeric micro- and nanoparticles.
    • The study highlights EHDA's potential for creating drug-loaded particles for controlled release applications.
    • Optimized processing parameters enable tunable particle characteristics for specific drug delivery needs.