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Association between microchimerism and multiple sclerosis in Canadian twins
Cristen J Willer1, Blanca M Herrera, Katie M E Morrison
1Department of Clinical Neurology, University of Oxford, Oxford, UK.
Journal of Neuroimmunology
|July 18, 2006
Summary
Microchimerism, the presence of foreign cells from previous pregnancies, is linked to multiple sclerosis (MS). This study found a significant association between microchimerism and MS in twins, suggesting a role in disease development.
Area of Science:
- Immunology
- Genetics
- Neurology
Background:
- Microchimerism, the presence of fetal cells in maternal circulation, is implicated in autoimmune diseases.
- The maternal parent-of-origin effect in multiple sclerosis (MS) lacks a clear explanation.
Purpose of the Study:
- To investigate the association between microchimerism and multiple sclerosis (MS) in twin pairs.
- To explore potential links between microchimerism and MS pathogenesis.
Main Methods:
- Analysis of microchimerism in monozygotic and dizygotic twin pairs discordant or concordant for MS.
- Comparison of microchimerism rates between affected and unaffected twins.
Main Results:
- Microchimerism was significantly associated with MS in affected females from concordant monozygotic twin pairs.
- Increased microchimerism was observed in affected females from dizygotic discordant pairs.
- Affected twins exhibited significantly higher rates of microchimerism compared to their unaffected co-twins.
Conclusions:
- These findings demonstrate a significant association between microchimerism and the presence of MS in twins.
- Microchimerism may play a role in the development or manifestation of multiple sclerosis.