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Updated: Jan 13, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
Published on: October 15, 2021
SVMHC: a server for prediction of MHC-binding peptides
Pierre Dönnes1, Oliver Kohlbacher
1Division for Simulation of Biological Systems, WSI/ZBIT, Eberhard Karls University, Tübingen Sand 14, D-72076 Tübingen, Germany. doennes@informatik.uni-tuebingen.de
Abstract:
Identification of MHC-binding peptides is a prerequisite in rational design of T-cell based peptide vaccines. During the past decade a number of computational approaches have been introduced for the prediction of MHC-binding peptides, efficiently reducing the number of candidate binders that need to be experimentally verified. Here the SVMHC server for prediction of both MHC class I and class II binding peptides is presented. SVMHC offers fast analysis of a wide range of alleles and prediction results are given in several comprehensive formats. The server can be used to find the most likely binders in a protein sequence and to investigate the effects of single nucleotide polymorphisms in terms of MHC-peptide binding. The SVMHC server is accessible at http://www-bs.informatik.uni-tuebingen.de/SVMHC/.
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