Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

BLAST: improvements for better sequence analysis.

Jian Ye1, Scott McGinnis, Thomas L Madden

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research
|July 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leaflet and Neoskirt Height in Transcatheter Heart Valves: Implications for Repeat Procedures and Coronary Access.

JACC. Cardiovascular interventions·2021
Same author

Metagenomic sequencing with spiked-in internal control to monitor cellularity and diagnosis of pneumonia.

The Journal of infection·2021
Same author

Alterations in Peripheral B Cell Subsets Correlate with the Disease Severity of Human Glaucoma.

Journal of inflammation research·2021
Same author

Five-year results of refractive outcomes and vision-related quality of life after SMILE for the correction of high myopia.

International journal of ophthalmology·2021
Same author

Quality-of-Life Outcomes After Transcatheter Aortic Valve Implantation in a "Real World" Population: Insights From a Prospective Canadian Database.

CJC open·2021
Same author

Ratiometric Raman nanotags enable intraoperative detection of metastatic sentinel lymph node.

Biomaterials·2021

The National Center for Biotechnology Information (NCBI) enhanced its Basic Local Alignment Search Tool (BLAST) server. These updates improve sequence similarity searching with better mismatch highlighting and faster results.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Basic Local Alignment Search Tool (BLAST) is a fundamental program for sequence similarity searching.
  • The National Center for Biotechnology Information (NCBI) hosts a widely used BLAST server.

Purpose of the Study:

  • To report recent enhancements to the NCBI BLAST server's results.
  • To improve the user experience and data presentation in sequence similarity searches.

Main Methods:

  • Implemented features to highlight mismatches between query and database sequences.
  • Integrated display of low-complexity sequence masking information.
  • Incorporated data from the NCBI Entrez system directly into BLAST results.
  • Optimized database sequence fetching for improved report generation speed.

Related Experiment Videos

Main Results:

  • Enhanced visualization of sequence alignments, including mismatches.
  • Clearer identification of low-complexity regions within query sequences.
  • Richer context for database sequences through Entrez integration.
  • Significantly faster generation of BLAST search reports.

Conclusions:

  • The recent enhancements to the NCBI BLAST server provide more informative and user-friendly sequence similarity search results.
  • Improved data integration and performance contribute to more efficient bioinformatics analyses.