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Published on: April 2, 2018
Semipreparative enantioseparation of Tröger base derivatives by HPLC
Sergey Sergeyev1, François Diederich
1Laboratory of Polymer Chemistry, Université Libre de Bruxelles, Belgium. sserguee@ulb.ac.be
Abstract:
We describe the enantioseparation of functionalized derivatives of the Tröger base by HPLC on commercially available chiral stationary phases. Cellulose-derived Chiralcel OJ and brush-type Whelk O1 are demonstrated to be complementary to each other in their scope. On the basis of the results obtained, the separation of selected compounds was successfully transferred onto semipreparative columns. We believe that the availability of enantiopure functionalized derivatives of the Tröger base will stimulate the further use of this interesting molecular scaffold in molecular recognition, asymmetric catalysis, and related areas of research and technology.
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