[The influence of cypramil on depressive disorders of behavior in young thyroidectomized male rats]

The activity of selective serotonin re-uptake inhibitor cypramil (cipramil, citalopram) has been studied in young male rats with thyroid hormone dysbalance induced by thyroidectomy. Thyroidectomy increased the level of depressed behavior in the Porsolt forced swim test and enhanced the expression of emotional behavior in the open-field test. The replacement treatment of thyroidectomized rats with triiodothyronine (T3) produced an antidepressant and anxiolytic effects. The chronic administration of cypramil also produced an antidepressant action in the Porsolt test, the drug effect being more pronounced in the case of a combined treatment with cypramil and T3 (synergism). Cypramil reduced the horizontal motor activity and the oprientation-research activity in the open-field test, but these drug effects were less pronounced in the case of joint administration with T3.