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Updated: Aug 7, 2026

Differentiation and Characterization of Neural Progenitors and Neurons from Mouse Embryonic Stem Cells
08:47

Differentiation and Characterization of Neural Progenitors and Neurons from Mouse Embryonic Stem Cells

Published on: May 15, 2020

Use of differentiating embryonic stem cells in pharmacological studies

Brigitte Wdziekonski1, Phi Villageois, Cécile Vernochet

  • 1Cellules Souches et Différenciation, Centre de Biochimie, Institut de Recherches Signalisation Biologie du Développement et Cancer, Nice, France.

Methods in Molecular Biology (Clifton, N.J.)
|July 19, 2006
PubMed

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...