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Related Experiment Videos

Folic acid as a Fenton-modulator: possible physiological implication.

Birija S Patro1, Soumyakanti Adhikari, Tulsi Mukherjee

  • 1Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai--400 085, India.

Medicinal Chemistry (Shariqah (United Arab Emirates))
|July 20, 2006
PubMed
Summary

Folic acid acts as a redox switch, modulating iron to protect cells from oxidative stress. It reduces iron toxicity by oxidizing iron and generating a potent intermediate, especially when ascorbic acid levels are low.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Nutritional Science

Background:

  • Cellular machinery is vulnerable to oxidative stress and iron overload.
  • Iron's redox activity contributes to cellular damage.
  • Folic acid's role in cellular protection is under investigation.

Purpose of the Study:

  • To investigate folic acid as an iron modulator.
  • To explore folic acid's potential in mitigating oxidative stress and iron toxicity.
  • To understand the mechanisms of folic acid's iron-modulating effects.

Main Methods:

  • Investigated folic acid's redox activity.
  • Assessed folic acid's capacity to oxidize iron, including chelated forms.
  • Identified and characterized folate-derived intermediates.

Related Experiment Videos

  • Evaluated the impact of biological reductants like ascorbic acid.
  • Confirmed iron-modulatory properties in L929 mouse fibroblast cell line.

    • Main Results:

    • Folic acid (1) functions as a redox switch, modulating iron concentration.
    • Folic acid oxidizes iron, even in chelated forms, reducing iron toxicity.
    • A folate-derived intermediate, 6-formyl pterin, exhibits enhanced Fe2+-oxidizing capacity.
    • This iron-oxidizing capacity is diminished by strong reductants like ascorbic acid but may be significant during pathogenesis.
    • Folic acid's iron-modulatory effects were validated in a cellular model.

    Conclusions:

    • Folic acid is a promising iron modulator with a dual mechanism for reducing iron toxicity.
    • Its efficacy may be particularly relevant in conditions of depleted ascorbic acid.
    • Folic acid offers a potential strategy for protecting cellular machinery against iron-induced oxidative damage.