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Human plasma DNP level after severe brain injury
Yi-lu Gao1, Hui-ning Xin, Yi Feng
1Department of Nuclear Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China. yilugao@hotmail.com
Summary
Elevated DNP levels in severe brain injury patients correlate with increased fluid loss and hyponatremia. This suggests DNP plays a role in the body's response to brain trauma.
Area of Science:
- Neuroscience
- Endocrinology
- Nephrology
Background:
- Severe brain injury can disrupt fluid and electrolyte balance.
- Hyponatremia and negative fluid balance are common complications post-brain injury.
- The role of DNP (dendronitrile polymer) in these complications is not fully understood.
Purpose of the Study:
- To investigate the relationship between DNP levels and hyponatremia in severe brain injury.
- To explore the association between DNP levels and fluid balance (isorrhea) after brain injury.
Main Methods:
- Peripheral venous plasma DNP concentrations were measured in 14 severe brain injury patients at 1, 3, and 7 days post-injury using radioimmunoassay.
- Control plasma DNP levels were obtained from 8 healthy volunteers.
- Daily plasma and urine electrolytes, osmotic pressure, and 24-hour fluid intake/output were monitored.
Main Results:
- Plasma DNP levels were significantly elevated in 8 of 14 patients from day 1 to day 3 post-injury compared to controls.
- Seven patients developed hyponatremia, and 8 experienced a negative fluid balance.
- Increased plasma DNP levels significantly correlated with negative fluid balance (r=-0.69, P<0.01) and hyponatremia (chi(2)=4.38, P<0.05).
Conclusions:
- Elevated DNP levels in severe brain injury are linked to enhanced natriuretic and diuretic responses.
- These responses contribute to the development of negative fluid balance and hyponatremia following brain injury.
- DNP may be a key factor in managing fluid and electrolyte disturbances after severe brain trauma.