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Hydroxyapatite cement based drug delivery systems: drug release in vitro
Journal of the Formosan Medical Association = Taiwan Yi Zhi
|October 1, 1991
Summary
This study introduces hydroxyapatite (HAP) cement as a novel skeletal drug delivery system. The HAP cement shows potential for treating bone infections by releasing antibiotics effectively.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Orthopedic Surgery
Background:
- Delivering high local concentrations of drugs to skeletal tissue is challenging.
- Existing methods may not achieve desired therapeutic effects for bone conditions.
Purpose of the Study:
- To develop and evaluate a self-setting hydroxyapatite (HAP) cement as a skeletal drug delivery system.
- To assess the feasibility of HAP cement for localized antibiotic delivery and bone regeneration.
Main Methods:
- Hydroxyapatite cement loaded with model antibiotics (cephalexin, norfloxacin) was prepared.
- In vitro release profiles of drugs from cement pellets (0.9-4.8% by weight) were analyzed.
- Drug release patterns were modeled using the Higuchi equation.
Main Results:
- The HAP cement demonstrated continuous in vitro drug release.
- Release kinetics correlated well with the Higuchi model, indicating predictable diffusion.
- The cement exhibited sufficient mechanical strength for potential bone grafting applications.
Conclusions:
- Self-setting hydroxyapatite cement is a viable system for skeletal drug delivery.
- This approach offers potential for treating osteomyelitis and infected compound fractures.
- HAP cement serves as a dual-purpose material for bone bonding and localized drug release.