Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cervical carcinogenesis with herpes simplex virus, type 2.

W B Wentz, J W Reagan, A D Heggie

    Obstetrics and Gynecology
    |August 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Acute degenerative, exudative, and proliferative glomerulonephritis superimposed on chronic diffuse glomerulonephritis.

    The Ohio State medical journal·2010
    Same author

    Latanoprost-induced pigmentation in human iridial melanocytes is fibroblast dependent.

    Experimental eye research·2004
    Same author

    Identification and quantification of ureaplasmas colonizing the respiratory tract and assessment of their role in the development of chronic lung disease in preterm infants.

    The Pediatric infectious disease journal·2001
    Same author

    Posttranslational regulation of acid sphingomyelinase in niemann-pick type C1 fibroblasts and free cholesterol-enriched chinese hamster ovary cells.

    The Journal of biological chemistry·2000
    Same author

    The pathogenesis of foam cell formation: modified LDL stimulates uptake of co-incubated LDL via macropinocytosis.

    Arteriosclerosis, thrombosis, and vascular biology·2000
    Same author

    Sterol synthesis is up-regulated in cholesterol-loaded pigeon macrophages during induction of cholesterol efflux.

    Journal of lipid research·1999
    Same journal

    The Political Determinants of Obstetric Prescribing.

    Obstetrics and gynecology·2026
    Same journal

    Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes: A Systematic Review and Meta-analysis.

    Obstetrics and gynecology·2026
    Same journal

    Milestones in Motion: Vaginal Birth After Cesarean.

    Obstetrics and gynecology·2026
    Same journal

    Ebola Virus in Pregnancy.

    Obstetrics and gynecology·2026
    Same journal

    A Quality-Improvement Study Evaluating Three Postpartum Prophylactic Oxytocin Rates and Blood Loss After Vaginal Birth.

    Obstetrics and gynecology·2026
    Same journal

    The Effects of Climate Change on Obstetric and Gynecologic Health.

    Obstetrics and gynecology·2026
    See all related articles

    Herpes simplex virus type 2 (HSV-2) may contribute to cervical cancer. Formalin-inoculated HSV-2 caused noninvasive cervical lesions in 76.8% and invasive adenocarcinoma in 30.2% of female mice.

    Area of Science:

    • Oncology
    • Virology
    • Gynecologic Pathology

    Background:

    • Recent studies suggest a correlation between herpes simplex virus type 2 (HSV-2) infection and uterine cervical lesions.
    • Previous research utilized clinical history or antibody detection to link HSV-2 and cervical cancer.
    • The carcinogenic potential of HSV-2 in the female reproductive tract requires further investigation.

    Purpose of the Study:

    • To evaluate the potential carcinogenic activity of formalin-inoculated herpes simplex virus type 2 (HSV-2) in the female mouse reproductive tract.
    • To establish a model system for studying cervical carcinogenesis, building on prior work with coal tar hydrocarbons.

    Main Methods:

    • Female mice were inoculated with formalin-treated herpes simplex virus type 2.
    • Cytologic and histologic preparations were analyzed from experimental and control groups.

    Related Experiment Videos

  • Mucosal alterations and tumor development in the cervix uteri were documented.

    • Main Results:

    • Noninvasive cervical lesions were identified in 76.8% of the experimental mice.
    • Invasive adenocarcinoma of the cervix was detected in 30.2% of the experimental mice.
    • Significant mucosal alterations and tumor formation were observed compared to controls.

    Conclusions:

    • Formalin-inoculated herpes simplex virus type 2 (HSV-2) demonstrates carcinogenic activity in the female mouse cervix.
    • HSV-2 is implicated as a potential oncogenic factor in cervical cancer development.
    • The study provides evidence supporting a role for HSV-2 in cervical carcinogenesis.