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[Transsphenoidal approach to prolactinomas].

O López-Arbolay¹, O Morales-Sabina, J L González-González

¹Servicio de Neurocirugía, Hospital Clínico Quirúrgico Hermanos Ameijeiras, Ciudad de la Habana, Cuba.

Neurocirugia (Asturias, Spain)

|July 21, 2006

Summary

Transsphenoidal surgery effectively treats prolactin-secreting pituitary tumors, normalizing prolactin levels in most cases and improving symptoms like headaches and visual deficits.

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Area of Science:

Neurosurgery
Endocrinology
Oncology

Context:

Prolactinomas are pituitary tumors causing hyperprolactinemia.
Medical treatment controls hyperprolactinemia and shrinks tumors in most cases.
The role of surgery in prolactinoma management remains debated.

Purpose:

Evaluate transsphenoidal microsurgical treatment outcomes for prolactin-secreting adenomas.
Assess tumor shrinkage, hormonal normalization, and symptom improvement post-surgery.

Summary:

Retrospective analysis of 63 patients undergoing transsphenoidal microsurgery for prolactinomas (1996-2003).
High rates of prolactin normalization (90.6% for microadenomas, 67.7% for macroadenomas).
Significant improvement in headaches (82%) and visual defects (69%). Transient diabetes insipidus occurred in 11 cases.

Impact:

Transsphenoidal adenomectomy is a safe and effective treatment for select prolactinomas.
Surgery offers significant symptom relief and hormonal normalization.
Provides a valuable surgical option when medical management is insufficient or contraindicated.

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