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Related Experiment Videos

Azapirones for generalized anxiety disorder.

C A Chessick1, M H Allen, Me Thase

  • 1University of Colorado Health Sciences Center, Psychiatry, 4455 E. 12th Avenue, A011-21, Devner, Colorado 80220, USA. cheryl.chessick@uchsc.edu

The Cochrane Database of Systematic Reviews
|July 21, 2006
PubMed
Summary

Azapirones, including buspirone, are effective for generalized anxiety disorder (GAD) compared to placebo, but may be less acceptable than benzodiazepines. Further long-term studies are needed for GAD treatment efficacy.

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Clinical Trials

Background:

  • Azapirones target the 5-HT1A receptor for generalized anxiety disorder (GAD) treatment.
  • Conflicting study results necessitate further investigation into their role as a first-line therapy for GAD.

Purpose of the Study:

  • To evaluate the efficacy and acceptability of azapirones in treating GAD.
  • To compare azapirones against placebo, other medications, and psychological treatments.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) from multiple databases (CCDANCTR, CENTRAL, MEDLINE, EMBASE, etc.) up to October 2005.
  • Inclusion criteria: RCTs of azapirones (e.g., buspirone) for GAD in all age groups.
  • Data extraction and analysis focused on GAD treatment outcomes versus placebo, other medications, and psychotherapy.

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Main Results:

  • Thirty-six RCTs involving 5908 participants were analyzed.
  • Azapirones demonstrated superiority over placebo for GAD treatment (NNT=4.4).
  • Azapirones may be less effective and less acceptable than benzodiazepines; comparative efficacy against antidepressants, kava kava, and psychotherapy remains inconclusive. Side effects were mild.

Conclusions:

  • Azapirones are beneficial for GAD, especially in patients not previously treated with benzodiazepines.
  • Acceptability may be lower than benzodiazepines, and long-term efficacy requires further investigation for this chronic condition.