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Updated: Aug 7, 2026
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
[Long-term follow-up study of nonischemic central retinal vein occlusion]
Ning Lu1, Guang-lu Wang, Feng Zhang
1Beijing Tongren Ophthalmic Center, Capital University of Medical Sciences, Beijing 100730, China. luningnl@yahoo.com.cn
Objective:
To explore the clinical characteristic, visual prognosis and related factors of nonischemic central vein occlusion.
Methods:
Retrospective data analysis (including visual acuity, color fundus photography and fundus fluorescein angiography) was conducted in patients with nonischemic CRVO who were followed-up for 3 years or longer.
Results:
The data of 35 cases (37 eyes) were analyzed. The follow-up time was 3 - 15 years, averaged 4.5 years. Age of those patients ranged from 18 to 76 years, averaged 56 years. Thirty cases (32 eyes) were over 40 years old. Two cases had chronic angle closure glaucoma. At the final visit, visual acuity improved in only 2 eyes (5%), remained the same in 11 eyes (30%), and decreased in 24 eyes (65%). Twenty-eight eyes (75%) had a final visual acuity of 20/200 or less. Nine eyes (24%) transformed to the ischemic type, among which neovascular glaucoma occurred in 5 eyes. Macular complications were the major causes of serious visual impairment. The patients with chronic angle closure glaucoma and partial optic nerve atrophy had relatively good final visual acuity.
Conclusions:
Nonischemic CRVO can cause severe visual impairment. Macular complications are the major causes of vision loss. Partial optic nerve atrophy may have a protective effect on visual acuity in CRVO.
