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Updated: Aug 7, 2026
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Evaluating Therapeutic and Chemical Toxicity Using Organ-Cultured Porcine Corneas and Epithelial Wound Healing
Published on: January 10, 2025
[Corneal permeability of topically applied pirenzepine solution]
Kai-di Wang1, Jin-song Zhang, Pan-shi Yan
1Department of Ophthalmology, First Teaching Hospital of Zhengzhou University, Zhengzhou 450052, China.
Summary
Adding azone or hyaluronic acid to pirenzepine eye drops significantly enhances corneal permeability. These combinations offer improved bioavailability compared to pirenzepine alone, with no observed irritation.
Area of Science:
- Ophthalmology
- Pharmacology
- Drug Delivery
Context:
- Pirenzepine is used for myopia control.
- Corneal permeability is crucial for ophthalmic drug efficacy.
- Optimizing drug delivery systems is essential for therapeutic outcomes.
Purpose:
- To evaluate the corneal permeability of pirenzepine eye drops.
- To compare the efficacy of pirenzepine alone versus combined with azone or hyaluronic acid.
- To provide data for the clinical application of enhanced pirenzepine formulations.
Summary:
- New Zealand white rabbits were administered pirenzepine, pirenzepine with hyaluronic acid, or pirenzepine with azone eye drops.
- Aqueous humor pirenzepine concentrations were measured using high-performance liquid chromatography (HPLC).
- Combinations with azone and hyaluronic acid showed significantly higher corneal permeability and bioavailability than pirenzepine alone, without causing irritation.
Impact:
- Azone and hyaluronic acid can effectively increase corneal permeability for pirenzepine.
- These findings support the development of improved pirenzepine eye drop formulations.
- Enhanced drug delivery may lead to better therapeutic results in ophthalmic treatments.
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