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Non-preventable mumps outbreaks in schoolchildren in Catalonia

Neus Cardeñosa1, Angela Domínguez, Neus Camps

  • 1Department of Health, Generalitat of Catalonia Barcelona, Spain.

Scandinavian Journal of Infectious Diseases
|July 22, 2006
PubMed

Insights

The Rubini mumps strain in the MMR vaccine may be linked to non-preventable mumps outbreaks in vaccinated children. This study investigated potential vaccine involvement in mumps cases in Catalonia.

Area of Science:

  • Epidemiology
  • Vaccinology
  • Public Health

Background:

  • The measles, mumps, and rubella (MMR) vaccine, particularly the Rubini mumps strain, was administered in Catalonia during 1994-1995.
  • Mumps outbreaks were reported in Catalonia between 1997 and 2002, prompting an investigation into their cause.

Purpose of the Study:

  • To assess the potential role of the MMR vaccine containing the Rubini mumps strain in non-preventable mumps outbreaks.
  • To determine the vaccine's contribution to mumps cases among vaccinated individuals.

Main Methods:

  • Retrospective analysis of mumps outbreaks reported in Catalonia from 1997 to 2000.
  • Examination of vaccination status and age demographics of individuals affected by mumps outbreaks.

Main Results:

  • Seventeen mumps outbreaks occurred between 1997-2000, with 14 in schoolchildren.
  • In 11 outbreaks, children were vaccinated; 10 were classified as non-preventable.
  • Sixty-six percent of investigated cases occurred in children vaccinated during 1994-1996.

Conclusions:

  • The MMR vaccine with the Rubini mumps strain may explain a significant proportion of mumps cases in vaccinated schoolchildren in Catalonia.
  • Findings suggest a potential association between this specific MMR vaccine strain and mumps outbreaks in vaccinated populations, consistent with international observations.

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