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[Human histocompatibility system association with gastrointestinal diseases]
Crésio Alves1, Nara Vieira, María Betânia P Toralles
1Faculdade de Medicina, Universidade Federal da Bahia. cresio.alves@uol.com.br
Acta Gastroenterologica Latinoamericana
|July 25, 2006
Summary
The human leukocyte antigen (HLA) system on chromosome 6 influences gastrointestinal disease susceptibility. Understanding HLA
Area of Science:
- Immunogenetics
- Gastroenterology
Context:
- The pathogenesis of gastrointestinal diseases involves complex interactions between genetic, immunological, and environmental factors.
- The human leukocyte antigen (HLA) system, located on chromosome 6, is highly polymorphic and plays a crucial role in immune responses, influencing disease susceptibility.
- Variations in HLA associations with diseases can differ based on the specific condition and ethnic-racial background.
Purpose:
- To review the structure, function, and detection methods of the HLA system.
- To explore the nomenclature of HLA alleles and their evolution.
- To discuss the association between HLA and specific gastrointestinal and oral diseases.
Summary:
- This review examines the human leukocyte antigen (HLA) system, its genetic basis, and its role in the pathogenesis of gastrointestinal disorders.
- It details HLA structure, function, typing methods, and nomenclature updates.
- Associations between HLA and celiac disease, Crohn's disease, autoimmune hepatitis, autoimmune pancreatitis, and recurrent oral ulcers are discussed.
Impact:
- Provides a comprehensive overview of the HLA system's relevance in gastrointestinal and oral diseases.
- Highlights the importance of HLA in understanding disease mechanisms, onset, and clinical course.
- Emphasizes the need for broader understanding and application of updated HLA typing and nomenclature in clinical practice and research.