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GC-based Detection of Aldononitrile Acetate Derivatized Glucosamine and Muramic Acid for Microbial Residue Determination in Soil
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Investigation of acetyl migrations in furanosides

O P Chevallier1, M E Migaud

  • 1School of Chemistry and Chemical Engineering, Queen's University, David Keir Building, Stranmillis Road, Belfast, BT9 5AG, Northern Ireland, UK. o.chevallier@qub.ac.uk

Beilstein Journal of Organic Chemistry
|July 25, 2006
PubMed

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Phase II Reactions: Acetylation Reactions01:24

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Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...