Related Experiment Video
Updated: Aug 7, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Subacute bacterial endocarditis presenting as polymyalgia rheumatica or giant cell arteritis
C Auzary1, D Le Thi Huong, X Delarbre
1Department of Internal Medicine, Centre Hospitalier Moulins-Yzeure, Moulins, France. c.auzary@ch-moulins-yzeure.fr
Objective:
To report on several patients with subacute bacterial endocarditis who were initially presumed, incorrectly, to have polymyalgia rheumatica or giant cell arteritis.
Methods:
We report 3 cases of subacute streptococcal endocarditis mimicking giant cell arteritis in 2 cases and polymyalgia rheumatica in one. We reviewed the literature through Medline search of French and English-language articles published between 1966 and 2005 and found 5 similar cases.
Results:
Shoulder and/or pelvic girdle pain was associated with neck or back pain in all patients. Scalp tenderness, bilateral jaw pain, amaurosis fugax were present in 2 patients. One patient had no fever. Two patients were treated with corticosteroids with initial good clinical response in one. Appropriate antibiotic therapy resulted in the rapid disappearance of rheumatic complaints in 2 patients and achieved a definitive cure of endocarditis in all cases.
Conclusion:
Rheumatologic symptoms may hinder the correct diagnosis of infective endocarditis in patients who present with a clinical picture suggesting polymyalgia rheumatica or giant cell arteritis. In such cases, blood cultures should be systematically drawn.
Insights
Subacute bacterial endocarditis can mimic polymyalgia rheumatica and giant cell arteritis, leading to misdiagnosis. Prompt blood cultures are crucial for accurate diagnosis and timely antibiotic treatment of infective endocarditis.
Area of Science:
- Rheumatology
- Infectious Diseases
- Internal Medicine
Background:
- Subacute bacterial endocarditis (SBE) can present with non-specific symptoms.
- Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are common rheumatologic conditions in older adults.
Observation:
- Three cases of SBE mimicking PMR or GCA are presented.
- A literature review identified five additional similar cases.
- Patients presented with shoulder and/or pelvic girdle pain, often with neck or back pain.
Findings:
- Two patients with SBE initially presented with symptoms suggestive of GCA, and one with symptoms of PMR.
- Some patients experienced scalp tenderness, jaw pain, or transient vision loss.
- Corticosteroid treatment provided temporary relief in one patient.
- Antibiotic therapy led to rapid resolution of rheumatic symptoms and cure of endocarditis.
Implications:
- Rheumatologic symptoms can obscure the diagnosis of infective endocarditis.
- Systematic blood cultures are essential in patients with suspected PMR or GCA who have atypical features.
- Early diagnosis and appropriate antibiotic treatment are critical for managing SBE.
Related Concept Videos
Rheumatic Heart Disease I: Introduction
Myocarditis II: Clinical Features and Diagnostic Tests
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis I: Introduction
Pericarditis II: Clinical Features and Diagnostic Tests