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A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
Metastatic melanoma and vitiligo: a case report
Marija Buljan1, Mirna Situm, Liborija Lugović
1University Department for Dermatology and Venereology, Sestre milosrdnice University Hospital, Vinogradska cesta 29, HR-10000 Zagreb, Croatia. marija.buljan1@zg.htnet.hr
Acta Dermatovenerologica Croatica : ADC
|July 25, 2006
Summary
Malignant melanoma (MM) and vitiligo can occur simultaneously, challenging the notion that vitiligo is always a positive prognostic indicator for MM. This case highlights potential shared mechanisms in melanocyte destruction for both conditions.
Area of Science:
- Dermatology
- Oncology
- Immunology
Background:
- Malignant melanoma (MM) and vitiligo are conditions linked to melanocytes.
- The relationship between MM and vitiligo is complex, with some studies suggesting depigmentation indicates a better prognosis for MM.
Observation:
- A 70-year-old female patient presented with metastatic MM in the right groin's lymphatic node.
- Simultaneously, she developed vitiligo-like depigmented patches on her face and extremities.
Findings:
- Despite the appearance of vitiligo, the patient later developed widespread lung metastases and metastases in the contralateral groin's lymphatic nodes.
- This case demonstrates the simultaneous occurrence of MM and vitiligo.
Implications:
- The simultaneous development of MM and vitiligo suggests shared underlying pathomechanisms.
- Further research is needed to explore the potential common pathways involved in the destruction of both benign and malignant melanocytes.
