Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular dynamics and BOLD fMRI: CBF level effects and analysis considerations.

Alberto L Vazquez1, Eric R Cohen, Vikas Gulani

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2108, USA. towi@umich.edu

Neuroimage
|July 25, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The alveolar edema equation.

Frontiers in physiology·2026
Same author

Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex.

Science advances·2026
Same author

A vendor-neutral functional MRI acquisition protocol for multi-site studies.

Aperture neuro·2026
Same author

Homozygous CHD8 mutation intensifies ASD phenotypes and attenuates sex differences.

Molecular psychiatry·2026
Same author

Chronic alteration of Ca<sup>2+</sup> and hemodynamic signals induced by intracortical microstimulation in the visual cortex of awake mice.

Biomaterials·2026
Same author

Layer-specific attentional modulation in the human primary somatosensory cortex.

Nature communications·2026

Altering baseline cerebral blood flow (CBF) significantly impacts hemodynamic responses. Lower baseline CBF leads to faster, higher amplitude blood oxygenation-level dependent (BOLD) and blood flow responses, crucial for fMRI analysis.

Area of Science:

  • Neuroimaging
  • Physiology
  • Biophysics

Background:

  • Cerebral blood flow (CBF) baseline levels critically influence hemodynamic responses.
  • Understanding these baseline effects is essential for accurate interpretation of functional magnetic resonance imaging (fMRI) data.

Purpose of the Study:

  • To characterize how baseline CBF affects the hemodynamic response.
  • To develop and validate models that can correct for baseline CBF effects in fMRI.

Main Methods:

  • Developed a vascular model separating arterial blood flow and venous blood volume responses.
  • Linked input stimuli to vascular responses to analyze baseline CBF effects.
  • Compared the vascular model's performance against an empirical hemodynamic model.

Related Experiment Videos

Main Results:

  • Increases in baseline CBF resulted in slower, lower amplitude BOLD and blood flow responses.
  • Decreases in baseline CBF led to faster, higher amplitude hemodynamic responses.
  • The vascular model predicted significant changes in arterial and venous time constants based on baseline CBF alterations.

Conclusions:

  • Both vascular and empirical models effectively captured baseline CBF effects on hemodynamic responses.
  • These models can be utilized to correct for baseline CBF variations in fMRI data.
  • The vascular model offers physiological insights, unlike simpler empirical models.