Aggregation of water-soluble block copolymers in aqueous solutions: recent trends

This review summarizes recent literature and some of our own results on aggregation behavior on water-soluble block copolymers belonging to three different classes viz. hydrophilic-hydrophobic (AB, ABA and BAB) block copolymers, double hydrophilic block copolymers (DHBCs) and ABC triblock copolymers. In the case of amphiphilic copolymers, special attention has been focussed on aggregation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers (Pluronics) and their aggregation in aqueous solutions at different temperatures as well as in the presence of various additives. Recent studies based on modern techniques viz. scattering (static and dynamic light scattering and small angle neutron scattering), spectral methods, e.g., fluorescence (static and time resolved), nuclear magnetic resonance and Fourier transform infrared spectroscopies, thermal methods e.g., differential scanning calorimetry and isothermal titration calorimetry, cryotransmission electron microscopy, ultrasonic absorption along with general physical properties like surface tension, viscosity and dye solubilization are summarized. For the DHBCs where one of the blocks is usually a polyion, complex formation by adding oppositely charged ions induces the formation of nanoaggregates. Characterization of such nanoaggregates of polyion complexes of DHBCs and their potential use for incorporation of ionic solutes in the micellar core are reviewed. The formation and characteristics of core-shell-corona micelles of ABC triblock copolymers and their applications as vehicles for controlled drug release are also discussed.