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Updated: Aug 7, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Bone-directed treatments for prostate cancer
1Uro-Oncology Clinic, Centre Hospitalier de l'Universite de Montreal, Hospital Notre-Dame, Department of Surgery/Urology, 1560 Rue Sherbrooke East, Montreal, Quebec H2L 4M1, Canada. Fred.saad@ssss.gouv.qc.ca
Hematology/Oncology Clinics of North America
|July 25, 2006
Summary
Men with advanced prostate cancer often have low bone mass, worsened by androgen deprivation therapy. Bone-directed therapies can help manage bone metastases and potentially prevent their development.
Area of Science:
- Oncology
- Bone Metabolism
- Prostate Cancer Therapeutics
Background:
- Advanced prostate cancer frequently presents with low bone mass.
- Androgen deprivation therapy (ADT) significantly decreases bone mineral density.
- Bone metastases cause substantial skeletal morbidity in prostate cancer patients.
Purpose of the Study:
- To review the impact of prostate cancer and its treatments on bone health.
- To discuss bone-directed therapies for managing bone metastases.
- To evaluate the role of bone-directed therapies in preventing bone metastases.
Main Methods:
- Literature review of studies on prostate cancer, bone health, and bone-directed therapies.
- Analysis of the effects of ADT on bone mineral density.
- Examination of clinical benefits of bisphosphonates, radio-nuclides, and endothelin-1 antagonists.
Main Results:
- Low bone mass is common in advanced prostate cancer.
- ADT exacerbates bone density loss.
- Bone-directed therapies offer palliative and therapeutic benefits for bone metastases.
- Intravenous bisphosphonates may prevent bone metastasis development.
Conclusions:
- Maintaining bone health is crucial for men with advanced prostate cancer.
- Bone-directed therapies are vital for managing skeletal complications.
- Early intervention with therapies like bisphosphonates could be preventative.
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