Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference...

Area of Science:

• Oncology
• Urology

Background:

• Advances in treatments, imaging, and molecular characterization have improved outcomes in advanced prostate cancer.
• Significant gaps in high-level evidence remain, impacting clinical practice for complex management aspects.

Framework:

• The Advanced Prostate Cancer Consensus Conference (APCCC) 2019 convened 72 international experts to address 10 controversial areas in advanced prostate cancer management.
• A modified Delphi process was used to develop 123 consensus questions, covering topics from locally advanced disease to managing treatment side effects.

Implementation:

• Experts anonymously voted on predefined questions, reflecting their opinions rather than formal literature reviews.
• Results indicate varying levels of expert support for different management approaches, detailed in supplementary materials.

Implications:

• The APCCC 2019 voting results provide a practical guide for clinicians and patients facing limited evidence in advanced prostate cancer management.
• Individualized treatment decisions, clinical trial enrollment, and further research are crucial for advancing care and improving patient outcomes.