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Functional subsets of allergen-reactive human CD4+ T cells
M L Kapsenberg1, E A Wierenga, J D Bos
1Laboratory of Cell Biology and Histology, Academisch Medisch Centrum, Amsterdam, The Netherlands.
Immunology Today
|November 1, 1991
Summary
The concept of human helper T (TH)-cell subsets is now widely accepted, supported by cytokine profile analyses. These studies highlight the significance of skewed TH1 and TH2 responses in chronic infections and hypersensitivity.
Area of Science:
- Immunology
- Cell Biology
Background:
- The classification of human helper T (TH)-cell subsets is increasingly recognized in immunology.
- This acceptance follows extensive research from multiple laboratories.
Purpose of the Study:
- To summarize current research on TH-cell subsets.
- To discuss the implications of skewed TH1 and TH2 responses.
Main Methods:
- Analysis of cytokine profiles from T-cell clones.
- Studies involving chronically-infected and hypersensitive individuals.
Main Results:
- Cytokine profile data support the existence of distinct TH-cell subsets.
- Evidence suggests a link between specific TH responses and disease states.
Conclusions:
- The concept of TH-cell subsets is validated by empirical data.
- Skewed TH1/TH2 responses are significant in understanding immune-mediated conditions.