Related Experiment Video
Updated: Aug 7, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Depression and anxiety during pregnancy and six months postpartum: a follow-up study
Liselott Andersson1, Inger Sundström-Poromaa, Marianne Wulff
1Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden. liselott.andersson@nll.se
Aims:
To investigate the relationship between antenatal and postpartum depression and anxiety and to explore associated maternal characteristics.
Methods:
From a population-based sample of 1,555 women attending two obstetric clinics in Sweden, all women with an antenatal psychiatric diagnosis (n = 220) and a random selection of healthy women (n = 500) were contacted for a second assessment three to six months postpartum. The Primary Care Evaluation of Mental Disorders was used for evaluation on both occasions.
Results:
Fewer cases of depressive and/or anxiety disorders were prevalent postpartum compared with the second trimester screening. Depression and/or anxiety were prevalent in 16.5% of postpartal women versus 29.2% of pregnant women. There was a significant shift from a majority of subthreshold diagnoses during pregnancy to full Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) diagnoses during the postpartum period. A history of previous psychiatric disorder, living single, and obesity were significantly associated with a new-onset postpartum psychiatric disorder. The absence of a previous psychiatric disorder was significantly associated with a postpartum recovery of depression or anxiety.
Conclusions:
Depression and anxiety appear to be less common postpartum than during pregnancy.
Related Concept Videos
Depression: Overview
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depressive Disorders: MDD and Dysthymia
Theory of Romantic Attachment in Adulthood

