Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Esmolol and beta-adrenergic blockade.

R L Wolman, M A Fiedler

    AANA Journal
    |December 1, 1991
    PubMed
    Summary
    This summary is machine-generated.

    Esmolol is a short-acting beta blocker for anesthesia, managing tachycardia by reducing myocardial oxygen demand. Its rapid metabolism ensures a short half-life, minimizing prolonged effects while requiring patient monitoring for potential side effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Eccentric exercises; why do they work, what are the problems and how can we improve them?

    British journal of sports medicine·2008
    Same author

    The mechanism for efficacy of eccentric loading in Achilles tendon injury; an in vivo study in humans.

    Rheumatology (Oxford, England)·2008
    Same author

    Current concepts in the management of tendon disorders.

    Rheumatology (Oxford, England)·2006
    Same author

    Assessing pain responses during general anesthesia.

    AANA journal·2002
    Same author

    Thermoregulation: anesthetic and perioperative concerns.

    AANA journal·2002
    Same author

    Preemptive analgesia applied to postoperative pain management.

    AANA journal·2002
    Same journal

    <i>AANA Journal</i> Course-GLP-1 Receptor Agonists: What CRNAs Need to Know About Their Expanding Role.

    AANA journal·2026
    Same journal

    Resident Registered Nurse Anesthetists' Use of Cognitive Enhancers in the U.S.

    AANA journal·2026
    Same journal

    Exploring the Safety and Efficacy of Gabapentin Use In Perioperative Analgesia Protocols: An Integrative Review.

    AANA journal·2026
    Same journal

    Substance Use Behaviors and Perceived Stress Among Resident Registered Nurse Anesthetists.

    AANA journal·2026
    Same journal

    Exploring the Relationship Between Job Satisfaction and Turnover Intentions Among CRNAs.

    AANA journal·2026
    Same journal

    Evaluating the Efficacy of Dexmedetomidine as an Adjunct to Local Anesthetics in Adductor Canal Blocks for Adult Patients Undergoing Primary Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.

    AANA journal·2026
    See all related articles

    Area of Science:

    • Anesthesiology
    • Cardiovascular Pharmacology

    Background:

    • Tachycardia during anesthesia increases myocardial oxygen demand, risking ischemia.
    • Anesthetic depth adjustments for tachycardia can be transient and ineffective.
    • Esmolol offers a unique solution for managing heart rate fluctuations in surgical settings.

    Purpose of the Study:

    • To evaluate the role and characteristics of esmolol in managing tachycardia in anesthesia.
    • To highlight esmolol's pharmacokinetic profile and clinical application.

    Main Methods:

    • Review of esmolol's properties as a beta-1 selective, short-acting beta blocker.
    • Discussion of esmolol's metabolism by red blood cell esterases, leading to a short half-life (9 minutes).
    • Description of administration via bolus doses or continuous infusion, with emphasis on loading doses.

    Related Experiment Videos

    Main Results:

    • Esmolol demonstrates strong beta-1 selectivity at clinical doses, decreasing as dosage increases.
    • Rapid metabolism results in minimal plasma presence 15 minutes post-bolus.
    • Metabolites are inactive and renally eliminated.

    Conclusions:

    • Esmolol is an effective agent for managing tachycardia in anesthesia due to its pharmacokinetic profile.
    • Appropriate dosing and patient monitoring are crucial to mitigate potential bradycardic and hypotensive effects.
    • Esmolol provides a manageable option for heart rate control in perioperative care.