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Oxygen supplementation during airway instrumentation improves intestinal barrier dysfunction
Ali Nayci1, Sibel Atis, Gulden Ersoz
1Department of Pediatric Surgery, Mersin University, School of Medicine, Mersin, Turkey. anayci@mersin.edu.tr
Airway instrumentation can harm the intestines and cause bacterial translocation. Oxygen supplementation during this procedure prevents hypoxemia, intestinal damage, and bacterial spread.
Area of Science:
- Physiology
- Gastroenterology
- Surgical Research
Background:
- Airway instrumentation is a common medical procedure.
- Potential adverse effects on intestinal health are not fully understood.
- Bacterial translocation is a significant clinical concern.
Purpose of the Study:
- To evaluate the impact of airway instrumentation on intestinal histopathology.
- To assess the role of bacterial translocation following the procedure.
- To determine if oxygen supplementation mitigates negative effects.
Main Methods:
- Wistar rats were divided into control and experimental groups.
- Experimental groups underwent airway instrumentation, with one receiving oxygen.
- Arterial blood gases, bacterial growth in tissues, and ileal histology were analyzed.
Main Results:
- Airway instrumentation led to hypoxemia, acidosis, and intestinal injury.
- Bacterial translocation to mesenteric lymph nodes occurred in 50% of rats without oxygen.
- Oxygen supplementation normalized blood gases, minimized histological damage, and reduced translocation.
Conclusions:
- Oxygen supplementation during airway instrumentation is protective.
- It effectively prevents hypoxemia and subsequent intestinal damage.
- This intervention significantly reduces bacterial translocation.
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