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Updated: Aug 7, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
Polymorphic ventricular tachycardia in the coronary care unit
Philip Varriale1, Marino Leonardi
1Division of Cardiology, Cabrini Medical Center of New York, New York, New York, USA.
Objective:
To describe the clinical experience of patients with polymorphic ventricular tachycardia (PMVT) in a hospital setting.
Methods:
A 2-year prospective, observational study of patients with symptomatic and asymptomatic PMVT admitted to the coronary care unit of a community medical center. Electrocardiograms were reviewed for a pattern diagnostic of PMVT, and the QTc interval of the baseline ECG was determined. Etiologic factors, management, and clinical outcomes were also analyzed.
Results:
The study included 27 patients (13 men) with a mean age of 66.6 +/- 10 years. Fourteen patients had a prolonged QTc interval >or=520 ms (group A), and 10 patients had a normal QTc interval
Conclusion:
PMVT with or without QTc prolongation is a sporadic tachyarrhythmia that has frequent malignant potential for cardiac arrest. Successful management mandates emergency defibrillation for cardiac arrest and other appropriate measures for suppression of PMVT. The prognosis of PMVT is improved when the cause is correctly identified and promptly treated.
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