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Updated: Oct 12, 2026

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Published on: May 12, 2019
[Antisecretory drugs, hypergastrinemia and hyperplasia of enterochromaffin-like cells (ECL)]
A Andriulli1, A Mangia, F Lawson
1Divisione di Gastroenterologia, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia.
Abstract:
A review of the literature was carried out in order to identify those mechanisms responsible for hyperplasia of Enterochromaffin-like cells (ECL) undergoing treatment with antisecretory drugs. All gastric acid secretion-inhibiting drugs cause a physiological increase in gastrinemia due to their inhibitory function. ECL hyperplasia is the consequence of the duration of hypergastrinemia. To date no factors responsible for the possible transformation of hyperplasia into carcinoma have yet been identified.
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Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples: